Legend Biotech halts Phase I clinical trial for LB1901

11 July 2022

In a filing with the US Securities and Exchange Commission, Legend Biotech (Nasdaq: LEGN) revealed it had notified the US Food and Drug Administration (FDA) that it has terminated its Phase I clinical trial under the Investigational New Drug (IND) application for LB1901, the US biotech’s investigational autologous chimeric antigen receptor T-cell (CAR-T) therapy for the treatment of adults with relapsed or refractory T-cell lymphoma.

Legend Biotech said that it has terminated this trial:

based on a lack of clinical benefit from a similar Legend Biotech CAR-T product candidate expressing the same CAR protein as LB1901 that was the subject of an investigator-initiated study conducted in China; and
in order to prioritize other product candidates in Legend Biotech’s pipeline.

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