Late-breaking results for adagrasib and pembrolizumab released by Mirati

6 December 2022

US clinical-stage cancer focused biotech Mirati Therapeutics (Nasdaq: MRTX) has announced preliminary results from the KRYSTAL-7 Phase II trial and KRYSTAL-1 Phase Ib cohort evaluating adagrasib (400mg twice daily) concurrently combined with Merck & Co’s (NYSE: MRK) blockbuster drug Keytruda (pembrolizumab) in patients for the treatment of first-line non-small cell lung cancer (NSCLC) harboring a KRASG12C mutation across all PD-L1 subgroups.

These data are the first to demonstrate the tolerability and feasibility of a concurrent combination regimen of a KRASG12C inhibitor and a PD-1/L1 checkpoint inhibitor, according to Mirati.

The company expects the largest advantage in patients with lower levels of PDL1, the protein targeted by Keytruda, and plans to launch a Phase III trial enrolling only those patients by the end of this year, according to Mirati chief executive David Meek in a comment to Reuters.

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