Kite's Yescarta CAR T-cell therapy shows strong OS
Primary overall survival (OS) analysis results of the Phase III ZUMA-7 study have been released by US biotech major Gilead Sciences’ (Nasdaq: GILD) subsidiary Kite.
The results showed a statistically-significant improvement for Yescarta (axicabtagene ciloleucel) in overall survival (OS) versus historical treatment, which was the standard of care (SOC) in a curative setting for nearly 30 years, for initial treatment of adult patients with relapsed/refractory large B-cell lymphoma (R/R LBCL) within 12 months of completion of first-line therapy.
The company pointed out that historical SOC is a multi-step process involving platinum-based salvage combination chemoimmunotherapy regimen followed by high-dose therapy (HDT) and stem cell transplant (ASCT) in those who respond to salvage chemotherapy. These findings will be presented in full later this year at an upcoming scientific meeting.
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