Kite and Arcellx ink multiple myeloma collaboration

9 December 2022

Shares of US biotech firm Arcellx (Nasdaq: ACLX) roared up almost 26% to $27.24 by mid-morning, on the revelation of lucrative collaboration for its lead late-stage product candidate, CART-ddBCMA.

Arcellx has entered a global strategic collaboration to co-develop and co-commercialize CART-ddBCMA with Gilead Sciences’ (Nasdaq: GILD) Kite unit, for the treatment of patients with relapsed or refractory multiple myeloma. Multiple myeloma is an incurable disease for most patients and the need remains for effective, safe, and broadly accessible therapies.

Currently in Phase II clinical development, CART-ddBCMA is an investigational cell therapy product comprising autologous T cells that have been genetically modified to target multiple myeloma. CART-ddBCMA utilizes Arcellx’ novel D-Domain binder. Kite and Arcellx will jointly advance the CART-ddBCMA asset.

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