Kite and Arcellx advance anito-cel multiple myeloma program
US anti-virals major Gilead Sciences’ (Nasdaq: GILD) Kite unit and Arcellx Nasdaq: ACLX) announced several key operational updates on their partnered anitocabtagene autoleucel (anito-cel) multiple myeloma program.
The collaboration was started in 2020 and expanded in November last year. Anito-cel is the first BCMA CAR T to be investigated in multiple myeloma that utilizes Arcellx’ novel and compact D-Domain binder.
The companies shared the design of a global, Phase III randomized controlled clinical trial, iMMagine-3, which Kite expects to start in the second half of this year. The trial will compare the efficacy and safety of anito-cel randomized against the standard of care (SOC) in patients with relapsed and/or refractory multiple myeloma (rrMM) who have received one to three prior lines of therapy, including an immunomodulatory drug (lMiD) and an anti-CD38 monoclonal antibody.
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