Kineta set to earn $359 million from chronic pain collaboration

17 April 2018

Seattle, USA-based biotech firm Kineta yesterday announced that it has entered into an exclusive option and license agreement with Swiss pharma giant Roche’s (ROG: SIX) US biotech subsidiary Genentech to develop Kineta’s α9/α10 nicotinic acetylcholine receptor (nAChR) antagonists for the treatment of chronic pain.

The α9/α10 nAChR is a novel target for the treatment of chronic neuropathic pain. Preclinical data showed investigational compounds that specifically target the receptor reduced pain behaviors in animal models and demonstrated disease-modifying effects including reduced inflammation and nerve protection at the site of the injury. This novel target is not believed to be expressed in the central nervous system and may lead to a safer therapy that is non-addictive and non-tolerizing.

Terms of the deal

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