Keytruda impact shown in liver cancer patients after sorafenib

19 January 2022

US pharma giant Merck & Co (NYSE: MRK) has announced the final results from the Phase III KEYNOTE-394 trial investigating Keytruda (pembrolizumab) plus best supportive care (BSC) in patients in Asia with advanced hepatocellular carcinoma (HCC) previously treated with sorafenib.

KEYNOTE-394 is the first trial with an anti-PD-1/L1 drug as a second-line monotherapy treatment to show an improvement in overall survival (OS), progression-free survival (PFS) and objective response rate (ORR) compared to placebo plus BSC for these patients.

Reduced risk of death

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