J&J combo surpasses Tagrisso in Phase III lung cancer test

8 January 2025

Johnson & Johnson (NYSE: JNJ) has announced potentially practice-changing data for its combination therapy of Rybrevant (amivantamab-vmjw) and Lazcluze (lazertinib).

Research shows the doublet demonstrated a significant overall survival (OS) benefit over AstraZeneca’s (LSE: AZN) Tagrisso (osimertinib), looking at first-line treatment of certain advanced or metastatic non-small cell lung cancers.

The MARIPOSA study, involving 1,074 patients, showed the therapy improved median OS by over one year compared to Tagrisso, building on earlier progression-free survival advantages.

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