Janssen enhances its portfolio in B-cell malignancies with licensing deal

2 May 2023

US healthcare giant Johnson & Johnson’s (NYSE: JNJ) Janssen Biotech subsidiary has entered into a worldwide collaboration and license agreement with China-based Cellular Biomedicine Group (Nasdaq: CBMG) to develop, manufacture and commercialize next-generation chimeric antigen receptor (CAR) T-cell therapies for the treatment of B-cell malignancies.

These investigational CD20-directed autologous CAR-Ts have demonstrated promising overall and complete response rates in Phase I studies in patients with relapsed/refractory non-Hodgkin’s lymphoma (NHL) in China, with the majority of study participants having diffuse large B-cell lymphoma (DLBCL), the most common type of aggressive lymphoma accounting for approximately one-third of B-cell lymphomas globally.

Terms of the accord

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