Intensity Therapeutics rockets on positive INT230-6 data

9 December 2023

Shares of Intensity Therapeutics (Nasdaq: INTS) skyrocketed 120% to $8.79 pre-market today, after it announced positive safety, tolerability, efficacy and immune activation data from the company’s Phase II INVINCIBLE trial of INT230-6 in patients with early-stage breast cancer without chemotherapy during the 2023 San Antonio Breast Cancer Symposium.

The trial showed that:

INT230-6 demonstrated a systemic increase in the median diversity of T-cell repertoire in patients’ blood compared to baseline that was also much larger than a control saline injection.
A single injection of INT230-6 demonstrated an increase in CD4 T-cells up to >95% necrosis of a tumor.
INT230-6 demonstrated an increase in CD4 T-cells ad NK cells within tumors.
Gene expression profiling revealed treatment effect of up-regulation of immune pathways expressed by T-cell activation, lymphocyte activation and inflammatory responses.
INT230-6 demonstrated a favorable safety profile and was well tolerated.

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