USA-based oncology specialist Eleven Biotherapeutics (Nasdaq: EBIO) has signed an agreement with the US National Cancer Institute (NCI) on the development of the company’s targeted therapeutic, vicinium, in combination with AstraZeneca’s Imfinzi (durvalumab).
The Cooperative Research and Development Agreement will evaluate the activity of vicinium, a single protein molecule composed of an antibody fragment genetically fused to a potent cytotoxic payload, alongside the Anglo-Swedish pharma major’s immune checkpoint inhibitor, in non-muscle invasive bladder cancer (NMIBC).
Under the terms of the agreement, the NCI will conduct a Phase I clinical trial in patients with high-grade NMIBC to evaluate the safety, efficacy, and biological correlates of the vicinium and durvalumab combination therapeutic strategy.
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