Imbruvica and Rituxan improve survival in CLL

5 December 2018

Combining the AbbVie (NYSE: ABBV) and Janssen drug Imbruvica (ibrutinib) with Roche’s (ROG: SIX) Rituxan (rituximab) brings improved survival compared to a chemo-immunotherapy regimen in previously untreated and younger chronic lymphocytic leukemia (CLL) patients.

That was the headline finding in Phase III data announced at the 2018 American Society of Hematology Annual Meeting this week.

This interim analysis showed that Imbruvica plus Rituxan, which is also marketed under the name MabThera, significantly prolonged progression-free survival, the primary endpoint of the study, compared to fludarabine, cyclophosphamide and Rituxan, with a 65% reduction in risk of progression or death.

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