Hillstream rockets on new data for ferroptosis candidate in NSCLC

11 February 2023

US biotech Hillstream BioPharma (Nasdaq: HILS), which is developing therapeutic candidates targeting drug resistant and devastating cancers using ferroptosis, saw its shares skyrocket 75% to $2.07 pre-market on Friday, and still closed up 35% at $1.59, after it released new clinical data on its lead candidate HSB-216.

The company announced initial results evaluating the synergy of HSB-1216 with immune checkpoint inhibitors in KRAS G12C-mutated non-small cell lung cancer (NSCLC) cells, Calu-1, with pembrolizumab, the blockbuster anti-PD-1 antibody sold by Merck & Co (NYSE: MRK) under the trade name Keytruda.

The study demonstrated significantly greater tumor inhibition of Calu-1 cells, when grown with human PBMCs (SEB-activated) and treated with HSB-1216 and pembrolizumab.

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