High-yield and high-throughput afucosylated mAb expression benefits therapeutic antibody efficacy

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The latest in a series of Industry Leader pieces from biological reagent supplier and service provider Sino Biological.

An absence of fucose residues on the antibody Immunoglobulin γ (IgG) constant (Fc) region N-glycan moiety has been demonstrated to increase the binding affinity to IgG-Fc-receptor (FcγR) IIIa. It results in increased antibody-dependent cellular cytotoxicity (ADCC) since this receptor is found on immune effector cells like natural killer cells. Sino Biological establishes a proprietary “FucoFree” eukaryotic cell culture system for the custom expression of afucosylated mAbs. We provide high-yield and high-throughput antibody expression with >95% purity and low endotoxin level (<1 EU/mg).