GSK and SpringWorks to end Blenrep combination collab
UK pharma major GSK (LSE: GSK) and US biotech SpringWorks Therapeutics (Nasdaq: SWTX) are to end their collaboration combining Blenrep (belantamab mafodotin) and Ogsiveo (nirogacestat).
The companies were hoping that GSK’s BCMA-targeting antibody-drug conjugate Blenrep and SpringWorks’ oral gamma secretase inhibitor Ogsiveo would work in multiple myeloma, and agreed to combine them in a global, non-exclusive license and collaboration agreement.
GSK and SpringWorks first started working together on the pairing in 2019 - later amending this collaboration in 2021 - in patients with relapsed or refractory multiple myeloma. The expanded agreement that was signed in 2022 allowed for studying the combination in earlier lines of treatment, including newly-diagnosed patients.
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