GlaxoSmithKline (LSE: GSK) has announced results from the Phase II proof of concept OSCAR study in COVID-19 with otilimab, an anti-granulocyte macrophage colony-stimulating factor (anti-GM-CSF) monoclonal antibody.
The primary endpoint of the OSCAR study was the proportion of COVID-19 patients who were alive and free of respiratory failure 28 days after treatment with a single dose of otilimab in addition to standard of care, including anti-viral treatments and corticosteroids, compared to patients being treated with standard of care alone.
"Patients aged 70 and over account for 70% of COVID-related deaths and nearly 40% of hospitalizations"Data from patients of all ages showed a treatment difference of 5.3%, but this did not reach statistical significance.
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