Green light for clinical testing of NK cell therapy for lupus nephritis

19 October 2023

Californian advanced therapy company Nkarta (Nasdaq: NKTX) is moving forward with plans to leverage the potential of natural killer (NK) cell-based treatments outside of oncology.

The company has been cleared by the US Food and Drug Administration to evaluate NKX019, an allogeneic, CD19-directed CAR NK cell therapy candidate, in lupus nephritis.

The approval of the firm’s Investigational New Drug (IND) application means Nkarta will now proceed with a dose escalation trial to test safety and clinical activity, with around a dozen patients being enrolled from early 2024.

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