Gilead stops Phase II trial of simtuzumab
US biotech company Gilead Sciences (Nasdaq: GILD) has stopped a Phase II clinical study into the investigational monoclonal antibody simtuzumab after evidence emerged that the treatment did not benefit patients.
Simtuzumab, which blocks the LOXL2 enzyme, was being trialled on patients with idiopathic pulmonary fibrosis (IPF) but unblinded efficacy and safety data by the study’s Data Monitoring Committee (MDC) revealed a lack of efficacy.
Phase II studies of the drug are continuing in patients with non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC).
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