Genentech files NDA for cobimetinib with Zelboraf in advanced melanoma

15 December 2014

Genentech, the US biotech subsidiary of Swiss Pharma major Roche Group (ROG: SIX), has submitted a New Drug Application for cobimetinib to the US Food and Drug Administration for treatment, in combination with Zelboraf (vemurafenib), for people with BRAF V600 mutation-positive advanced melanoma.

The submission is based on results of the coBRIM Phase III study, which showed people who received the MEK inhibitor cobimetinib plus Zelboraf lived significantly longer without their disease worsening or death (progression-free survival; PFS) compared to Zelboraf alone.

Under development with Exelixis

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