Fresh failure leaves Fasenra nearly out of COPD running

30 May 2018

The chances of Fasenra (benralizumab) adding to its existing approval as an add-on treatment for severe eosinophilic asthma by proving its efficacy in chronic obstructive pulmonary disease (COPD) now look slim.

AstraZeneca’s (LSE: AZN) first respiratory biologic has failed its second Phase III trial in moderate to very severe COPD by not meeting the primary endpoint of a statistically-significant reduction of exacerbations.

Earlier this month it was revealed that the first pivotal Phase III trial had not met its primary endpoint either.

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