First-in-class antibody secures strong late-stage data package

16 December 2022

Positive results from the Phase III GLOW trial could pave the way for a new kind of cancer treatment, an antibody targeting the Claudin-18.2 protein.

Developed by Japanese drugmaker Astellas Pharma (TYO: 4503), zolbetuximab is being tested, in combination with chemo, for the first-line treatment of advanced gastroesophageal junction (GEJ) cancers.

The company, which has already announced positive top-line results from the companion SPOTLIGHT trial, is also testing zolbetuximab in combination with the checkpoint blocker Keytruda (pembrolizumab), in the Phase II ILLUSTRO study.

This article is accessible to registered users, to continue reading please register for free. A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.

Try before you buy

Free

7 day trial access

Take a Free Trial

All the news that moves the needle in pharma and biotech
Exclusive features, podcasts, interviews, data analyses and commentary from our global network of life sciences reporters.
Receive The Pharma Letter daily news bulletin, free forever.

Become a subscriber

£820

Or £77 per month

Subscribe Now

Unfettered access to industry-leading news, commentary and analysis in pharma and biotech.
Updates from clinical trials, conferences, M&A, licensing, financing, regulation, patents & legal, executive appointments, commercial strategy and financial results.
Daily roundup of key events in pharma and biotech.
Monthly in-depth briefings on Boardroom appointments and M&A news.
Choose from a cost-effective annual package or a flexible monthly subscription

The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed

Chairman, Sanofi Aventis UK