First-in-class antibody secures strong late-stage data package

16 December 2022
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Positive results from the Phase III GLOW trial could pave the way for a new kind of cancer treatment, an antibody targeting the Claudin-18.2 protein.

Developed by Japanese drugmaker Astellas Pharma (TYO: 4503), zolbetuximab is being tested, in combination with chemo, for the first-line treatment of advanced gastroesophageal junction (GEJ) cancers.

The company, which has already announced  positive top-line results from the companion SPOTLIGHT trial, is also testing zolbetuximab in combination with the checkpoint blocker Keytruda (pembrolizumab), in the Phase II ILLUSTRO study.

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