Fewer headaches, but Phase III data for Alder's biologic fail to impress

28 June 2017

USA-based drug developer Alder BioPharmaceuticals (Nasdaq: ALDR) has lost a quarter of its share price after announcing Phase III results from a trial of migraine candidate eptinezumab.

While the trial achieved its primary endpoint and key secondary endpoints, investors were likely disappointed by efficacy data which showed only a slight improvement over placebo.

In a highly competitive market for new migraine treatments, Alder’s investigational biologic, which is administered quarterly via infusion, is up against Amgen’s (Nasdaq: AMGN) erenumab, Eli Lilly’s (NYSE: LLY) galcanezumab and Teva Pharmaceutical’s (NYSE: TEVA) fremanezumab.

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