Enthusiasm for checkpoint inhibitor combo trials shows no sign of abating
Combinations involving checkpoint therapies are starting to be used as the standard of care in certain metastatic cancer types, such as Merck & Co’s (NYSE: MRK) Keytruda (pembrolizumab) with chemotherapy in advanced squamous non-small cell lung cancer, according to data and analytics company GlobalData.
Among the six approved checkpoint inhibitors - Keytruda, Bristol-Myers Squibb’s (NYSE: BMY) Opdivo (nivolumab) and Yervoy (ipilimumab), AstraZeneca’s (LSE: AZN) Imfinzi (durvalumab), Roche’s (ROG: SIX) Tecentriq (atezolizumab), and Merck KGaA (MRK: DE)/Pfizer’s (NYSE: PFE) Bavencio (avelumab) - the majority of ongoing Phase I to Phase III clinical trials involve a combination regimen.
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