Enhertu closer to becoming first tumor-agnostic HER2-directed therapy and ADC

29 January 2024

The US supplemental Biologics License Application (sBLA) for Enhertu (trastuzumab deruxtecan) has been accepted and granted Priority Review for patients with unresectable or metastatic HER2-positive (immunohistochemistry [IHC] 3+) solid tumors who have received prior treatment or who have no satisfactory alternative treatment options.

AstraZeneca (LSE: AZN) and Daiichi Sankyo's (TYO: 4568) sBLA is based on data from the ongoing DESTINY-PanTumor02 Phase II trial.

"Reflects the potential of this medicine to redefine the treatment of HER2-expressing cancers"

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