End of the line for Inspirna as biotech sector faces strain

1 April 2025

US oncology biotech Inspirna is winding down after a decade of operations, according to a LinkedIn post from chief executive Usman Azam.

He said the New York-based company would close after “ten fantastic years,” while thanking patients involved in clinical trials as well as the scientific founders and investors who supported the business since its formation.

Inspirna’s lead asset was ompenaclid (RGX-202), a CKB/SLC6A8 pathway-targeting candidate developed for advanced gastrointestinal cancers, including those with RAS mutations. Acknowledging Merck KGaA’s (MRK: DE) collaboration on the drug, Mr Azam did not say what will happen to the program or the deal.

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