Effective pairing proves elusive for Lumakras
Disappointing results for Amgen’s (Nasdaq: AMGN) Lumakras (sotorasib) underscore the development difficulties associated with a target which has historically been regarded as undruggable.
In a small trial, a combination of Lumakras and the tyrosine kinase blocker Gilotrif (afatinib), developed by Boehringer Ingelheim, shrank tumors in 35% of people.
Meanwhile, a combination of Lumakras and a MEK blocker, Mekinist (trametinib), generated a partial response in 20% of people who had not been treated with a KRAS blocker before. Mekinist is developed by Novartis (NOVN: VX).
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