Earlier use of Abecma shows beneficial effect in multiple myeloma

10 August 2022

Positive top-line results from a Phase III trial of the first CAR T-cell therapy in multiple myeloma have been presented by developers Bristol Myers Squibb (NYSE: BMY) and 2seventy bio (Nasdaq: TSVT).

The KarMMa-3 study is comparing Abecma (idecabtagene vicleucel) with standard combo regimens in adults with relapsed and refractory disease which has resisted two to four prior lines of therapy.

At a prespecified interim analysis, data show the trial met its primary endpoint of demonstrating a statistically-significant improvement in progression-free survival (PFS).

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