Disappointment for CymaBay echoes wider struggle in NASH
Shares in CymaBay Therapeutics (Nasdaq: CBAY) fell by about 50% on Tuesday, after 12-week top-line results showed the firm’s non-alcoholic steatohepatitis (NASH) candidate seladelpar failed to outperform placebo.
It is the latest in a series of depressing clinical readouts for NASH candidates, after Gilead’s (Nasdaq: GILD) high profile failure with selonsertib, and a mixed picture for Intercept Pharmaceuticals' (Nasdaq: ICPT) obeticholic acid (OCA).
CymaBay investors will remain optimistic that seladelpar, a peroxisome proliferator-activated receptor delta (PPARδ) agonist, boasts strong Phase II data in primary biliary cholangitis (PBC).
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