Dermavant’s AD drug not just making up the numbers
US immuno-dermatology specialist biotech Dermavant Sciences, a subsidiary of Roivant Sciences, has achieved positive Phase III trial results with Vtama (tapinarof), a nonsteroidal, topical AhR-modulating agent, in atopic dermatitis (AD).
The promising results, which prompted the US Food and Drug Administration (FDA) to accept Dermavant’s supplemental new drug application, may bring the product closer to market authorization and will be the company’s first marketed drug in AD, subject to approval, according to GlobalData, a leading data and analytics company.
Vtama works by activating the NRF-2 pathway, modulating type 17 helper T cytokines and inducing antioxidative enzymes, thereby inhibiting inflammatory pathways.
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