Deaths spell the end for MacroGenics trial

11 July 2022

Shares in USA-based biopharma MacroGenics (Nasdaq: MGNX) were more than 10% down during Monday morning’s early trading.

The cancer-focused antibody company had announced the closure of the Phase II study, CP-MGA271-06.

"We were surprised by the emergence of these events"This trial was evaluating the investigational regimen of enoblituzumab, an Fc-optimized B7-H3-directed monoclonal antibody, in combination with either retifanlimab, an anti-PD-1 monoclonal antibody, or tebotelimab, a PD-1 × LAG-3 bispecific DART molecule, in the first-line treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN).

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