CytomX to seek partner for cancer candidate praluzatamab ravtansine

7 July 2022

US oncology biotech CytomX Therapeutics’ (Nasdaq: CTMX) shares were down more than 25% at $1.47 in pre-market trading, after the company revealed that the latest clinical data on its praluzatamab ravtansine did not support further development alone.

Late Wednesday, CytomX announced that the Phase II study of praluzatamab ravtansine in patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2 (HER2)-non-amplified breast cancer (Arm A) met its primary efficacy endpoint of confirmed objective response rate (ORR) of greater than 10 percent by central radiology review. Praluzatamab ravtansine is a DM4-conjugated, conditionally activated antibody-drug conjugate (ADC) targeting CD166 and is wholly owned by CytomX.

However, Arm B did not pass protocol-defined futility boundary (ORR was less than 10%) in patients with advanced triple-negative breast cancer (TNBC) and enrollment into Arms B and C will be discontinued.

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