Cyclacel shares fall a quarter on Phase III failure

27 February 2017

New Jersey, USA-headquartered Cyclacel Pharmaceuticals (Nasdaq: CYCC) suffered a major blow Thursday, as the company announced its leukemia candidate sapacitabine (CYC682) had failed to reach the primary endpoint in a pivotal trial.

Top-line results show that sapacitabine did not achieve a statistically-significant improvement in overall survival. The company’s share price has fallen by a quarter since the announcement was made.

An improved rate of complete remission, a secondary endpoint, was observed in patients who had discontinued therapy at the time of analysis. Other endpoints and safety data were similar between the arms.

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