Cracks appear in Solid Biosciences after early trial results

8 February 2019

The value of shares in Solid Biosciences (Nasdaq: SLDB) fell by around two-thirds on Thursday, after the firm acknowledged negative preliminary results from the Phase I/II IGNITE DMD trial.

The firm is testing its microdystrophin gene transfer candidate, labeled SGT-001, for the treatment of Duchenne muscular dystrophy (DMD).

After three months, low levels of microdystrophin protein expression were detected, leading investors to worry that the candidate will not be effective.

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