Corbus tanks as lenabasum Phase III fails in systemic sclerosis

9 September 2020

Shares in US biotech Corbus Pharmaceuticals (Nasdaq: CRBP) plummeted nearly 76% to $2.23 by close of trading on Monday, after the US drugmaker said that top-line data showed no significant differences in the primary and secondary endpoints when comparing its lead candidate lenabasum to placebo, both added to background drug therapy.

The data were from the 52-week Phase III RESOLVE-1 study of lenabasum in patients with diffuse cutaneous systemic sclerosis (SSc). SSc is a rare and life-threatening multi-system autoimmune disease for which there are currently no US Food and Drug Administration-approved treatments for overall disease.

Lenabasum, an oral synthetic endocannabinoid-mimetic that preferentially binds to the cannabinoid receptor type 2 (CB2).

This article is accessible to registered users, to continue reading please register for free. A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.

Try before you buy

Free

7 day trial access

Take a Free Trial

All the news that moves the needle in pharma and biotech
Exclusive features, podcasts, interviews, data analyses and commentary from our global network of life sciences reporters.
Receive The Pharma Letter daily news bulletin, free forever.

Become a subscriber

£820

Or £77 per month

Subscribe Now

Unfettered access to industry-leading news, commentary and analysis in pharma and biotech.
Updates from clinical trials, conferences, M&A, licensing, financing, regulation, patents & legal, executive appointments, commercial strategy and financial results.
Daily roundup of key events in pharma and biotech.
Monthly in-depth briefings on Boardroom appointments and M&A news.
Choose from a cost-effective annual package or a flexible monthly subscription

The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed

Chairman, Sanofi Aventis UK