Collaboration on lonodelestat in COVID-19-related ARDS

27 April 2020

Shares of Swiss biotech firm Santhera Pharmaceuticals (SIX: SANN) were up 26.75% to 10.14 Swiss francs in early trading, after the company announced a COVID-19 related collaboration.

Santhera has joined forces with Cold Spring Harbor Laboratory (CSHL) to investigate lonodelestat (POL6014), a potent inhibitor of human neutrophil elastase (hNE), as a therapeutic intervention for COVID-19-related acute respiratory distress syndrome (ARDS), a frequent result of the novel coronavirus.

The company acquired rights to POL6014 in 2018 from fellow Swiss firm Polyphor, in a deal that involved an upfront payment of around $7 million plus additional cash payments of up to 121 million francs ($124 million) contingent on future development, regulatory and particularly sales milestones

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