Cataracts put the kibosh on Kodiak's tarcocimab

25 July 2023

Kodiak Sciences (Nasdaq: KOD) lost 47% of its stock market value on Monday after presenting top-line results from three Phase III studies of tarcocimab tedromer, an antibody biopolymer conjugate.

The DAYLIGHT study was a randomized, double-masked, active comparator-controlled study evaluating the efficacy and safety of a high intensity dosing regimen of tarcocimab tedromer in 557 treatment-naïve subjects with wet age-related macular degeneration (AMD).

This study met the primary endpoint of non-inferior visual acuity gains for tarcocimab dosed monthly compared to aflibercept dosed every eight weeks following three monthly loading doses. Tarcocimab was safe and well tolerated in the study and with a low rate of intraocular inflammation.

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