CANbridge gains ex-North America rights to AVEO's AV-203

22 March 2016

The USA’s AVEO Oncology (Nasdaq: AVEO) has entered into an exclusive collaboration and license agreement with Chinese privately-held biopharma firm CANbridge Life Sciences, granting the latter worldwide rights, excluding the USA, Canada and Mexico, to AV-203, AVEO’s clinical-stage ErbB3 (HER3) inhibitory antibody candidate

CANbridge plans to develop AV-203 first in esophageal squamous cell cancer (ESCC), the most prevalent form of esophageal cancer. According to the World Health Organization, esophageal cancer is the eighth most common cancer globally, with over 450,000 cases diagnosed each year. To date, AVEO has completed a Phase I, open-label, dose-escalation study of AV-203 in patients with advanced solid tumors. In this study, AV-203 was found to be generally safe and well-tolerated, with an early signal of activity consistent with preclinical data showing the potential for heregulin, the only known ligand for ErbB3, to serve as a biomarker predictive of AV-203 anti-tumor activity.

AVEO eligible for up to $133 million in milestones

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