Broader indication for AstraZeneca and Daiichi Sankyo's Enhertu across Europe

19 July 2022

AstraZeneca (LSE: AZN) and Daiichi Sankyo’s (TYO: 4568) Enhertu (trastuzumab deruxtecan) has been approved in the European Union (EU) as a monotherapy for the treatment of adults with unresectable or metastatic HER2-positive breast cancer who have received one or more prior anti-HER2-based regimens.

This approval broadens the indication for the HER2-directed antibody drug conjugate across Europe to earlier use in HER2-positive metastatic breast cancer.

"Potential for this medicine to set a new benchmark in the treatment of HER2-positive metastatic breast cancer"The submission was based on the DESTINY-Breast03 results in which Enhertu demonstrated a 72% reduction in the risk of disease progression or death versus trastuzumab emtansine, a drug developed under the brand name Kadcyla by the Roche (ROG: SIX) subsidiary Genentech.

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