Bristol-Myers Squibb and Gritstone collaborate on immunotherapy
US pharma major Bristol-Myers Squibb (NYSE: BMY) has entered into a clinical trial collaboration immuno-oncology firm Gritstone Oncology to evaluate the safety and tolerability of Gritstone’s personalized neoantigen immunotherapy, GRANITE-001.
This comprises sequential delivery of neoantigens to patients within an adenovirus-based vector (prime) and a self-replicating RNA-based vector (boost), in combination with B-MS’
programmed death-1 (PD-1) immune checkpoint inhibitor, Opdivo (nivolumab), and Opdivo plus Yervoy (ipilimumab), in patients with advanced solid tumors.
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