Bristol-Myers' Phase III CheckMate -498 study misses goal in glioblastoma
Although approved in a number of cancer indications and bringing significant revenues for US pharma major Bristol-Myers Squibb’s (NYSE: BMY), Opdivo (nivolumab) has seen another trial failure in the hard-to-treat brain cancer glioblastoma.
B-MS today announced the Phase III CheckMate -498 trial evaluating Opdivo plus radiation versus temozolomide plus radiation in patients with newly-diagnosed O6-methylguanine-DNA methyltransferase (MGMT)-unmethylated glioblastoma multiforme (GBM) did not meet its primary endpoint of overall survival (OS) at final analysis.
The safety profile of Opdivo, which generated first-quarter 2019 sales of $1.8 billion, was consistent with previously reported studies in solid tumors. The company will complete a full evaluation of the data from CheckMate -498 and work with investigators on the future presentation and publication of the results. B-MS shares were down more than 1.1% at $46.94 just ahead of mid-day New York trading,
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