Brii Bio antibody impactful against Omicron and other variants
China-based Brii Biosciences (HKG: 2137) has announced new live virus data confirming that the amubarvimab/romlusevimab combination, a long-acting COVID-19 monoclonal antibody therapy, retains neutralizing activity against the Omicron BA.4/5 and BA.2.12.1 SARS-CoV-2 subvariants.
The drug combination is already approved in China for the treatment of adults and pediatric patients with COVID-19 at high risk for progression to severe disease. In July 2022, the amubarvimab/romlusevimab combination was made commercially available in China.
Human pharmacokinetic data from the University of Maryland indicates that total serum concentrations of the combination will remain above the level required for neutralizing activity against the subvariants. As a result, adequate therapeutic exposures are expected to persist throughout the treatment period.
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