Breyanzi works in broadest array of B-cell malignancies of any CD19-directed CAR-T therapy, says BMS

2 May 2023

Bristol Myers Squibb (NYSE: BMY) has announced positive top-line results from two studies on Breyanzi (lisocabtagene maraleucel), its CD19-directed CAR-T cell therapy.

The data is from TRANSCEND FL, a Phase II, single-arm study in relapsed or refractory follicular lymphoma (FL), and TRANSCEND NHL 001, a Phase I, single-arm study in relapsed or refractory B-cell non-Hodgkin lymphoma, including mantle cell lymphoma (MCL).

Results showed both studies met the primary endpoint of overall response rate, with Breyanzi demonstrating statistically significant and clinically meaningful responses in relapsed or refractory FL and MCL.

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