Breakthrough status in cystic fibrosis sends Proteostasis up by half

13 March 2018

The cystic fibrosis (CF) specialist Proteostasis Therapeutics (Nasdaq: PTI) made gains of 47% in Tuesday morning’s trading as it entered the afternoon at $6.13 per share.

Investors were reacting to news that the company has received Breakthrough Therapy designation from the US Food and Drug Administration (FDA) for PTI-428, its CF transmembrane conductance regulator (CFTR) amplifier.

The status applies for the treatment of CF in homozygous patients for the F508del mutation who are receiving Vertex Pharmaceuticals’ (Nasdaq: VRTX) Orkambi (lumacaftor/ivacaftor) as background therapy.

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