BMS declines option on two Exscientia oncology candidates

15 March 2023

UK-based company that uses artificial intelligence (AI) in drug discovery Exscientia (Nasdaq: EXAI) saw its shares edge up 2.8% to $6.86 in morning trading today, despite announcing that US pharma major Bristol Myers Squibb (NYSE: BMY) would not be taking up an option under an agreement with Celgene.

As a result, Exscientia now wholly-owns precision oncology development candidates, EXS74539 (‘539), an LSD1 inhibitor, and EXS73565 ('565), a MALT1 protease inhibitor.

These compounds have been precision designed to improve the potential for patient benefit and solve complex design issues that may limit the probability of success of other compounds in development. Investigational new drug (IND)-enabling studies are underway and the company expects to provide an update on clinical development plans leveraging Exscientia's personalized medicine platform in the second half of 2023.

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