Blow for LAG-3 combo as Bristol Myers scraps colon cancer trial

18 December 2023

New Jersey, USA-based cancer company Bristol Myers Squibb (NYSE: BMY) has announced that the Phase III RELATIVITY-123 trial will be stopped, based on a futility analysis.

The trial has been evaluating a fixed-dose combination of the firm’s checkpoint blocker Opdivo (nivolumab) and LAG-3 blocker, relatlimab-rmbw.

People in the trial had a certain form of metastatic colorectal cancer, with disease which had progressed following at least one, but no more than four, prior lines of therapy.

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