Bivalent boosters better against Omicron than original Spikevax, Moderna says

15 November 2022

Moderna (Nasdaq: MRNA) has announced that both of its bivalent Omicron-targeting booster candidates trigger a superior antibody response compared to a booster of mRNA-1273, the firm's prototype vaccine, against Omicron, in Phase II/III trials.

Both bivalent vaccines, which are currently known as mRNA-1273.214 and mRNA-1273.222, also met non-inferiority immunogenicity criteria to the original strain.

"We are pleased to see that both of our bivalent booster vaccine candidates offer superior protection against Omicron BA.4/BA.5 variants compared to our original booster"

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