Biotie's Parkinson's drug tozadenant clears Phase IIb study
Finland-based biotechnology firm Biotie Therapies has reported encouraging data from a study of its
Parkinson's disease candidate tozadenant, which is partnered with UCB.
The Phase IIb study evaluated the adenosine A2a antagonist in Parkinson's disease (PD) patients who
were starting to experience a wearing-off in the effectiveness of their levodopa therapy.
Motor fluctuations tend to occur after prolonged treatment with dopamine-based therapy such as
levodopa, with the first sign typically that the effects of one dose do not last until the next is due.
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