Biogen Idec reports positive results from Phase II trial of anti-LINGO-1 in acute optic neuritis
US biotech firm Biogen Idec (Nasdaq: BIIB) has announced positive top-line results from its Phase II trial of anti-LINGO-1 in acute optic neuritis.
The RENEW trial showed treatment with anti-LINGO-1 demonstrated evidence of biological repair of the visual system, and that it demonstrated an improvement in the recovery of optic nerve latency, which was the study’s endpoint. This was measured by full field visual evoked potential (FF-VEP), relative to placebo.
The study showed no effect on secondary endpoints, including change in thickness of the retinal layers (optic nerve neurons and axons) and visual function, as measured by spectral domain optical coherence tomography (SD-OCT) and low contrast letter acuity, respectively.
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