Azeliragon fails Ph III endpoints in Alzheimer's, but vTv keeps faith

13 June 2018

USA-based vTv Therapeutics (Nasdaq: VTVT) saw its shares plunge 22.75% to $1.46 in pre-market trading after it revealed another disappointment in the development of its Alzheimer’s disease candidate, notching up another AD failure this week alone.

vTv announced that results from Part B of the company’s STEADFAST Study of the investigational medication azeliragon in people with mild Alzheimer’s disease did not meet co-primary efficacy endpoints.

The pre-specified subgroup consisted of azeliragon-treated patients with maximal azeliragon plasma concentrations of less than 7.5ng/mL and baseline Mini Mental State Examination (MMSE) scores between 19 and 27, and the endpoints were statistically-significant improvement in cognitive or functional outcomes as measured by the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) and Clinical Dementia Rating Scale Sum of Boxes (CDR-sb) at 12-months compared to placebo.

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