AstraZeneca to fully acquire Caelum Bioscience

29 September 2021

Anglo-Swedish pharma major AstraZeneca’s (LSE: AZN) recently-acquired Alexion rare diseases unit has exercised its option to acquire all remaining equity in Caelum Biosciences, along with its for CAEL-101, a potentially first-in-class fibril-reactive monoclonal antibody (MAb) for the treatment of light chain (AL) amyloidosis.

AstraZeneca’s shares were up 3% at 8,730.00 pence in London trading by midday today.

CAEL-101 is currently being evaluated in the Cardiac Amyloid Reaching for Extended Survival (CARES) Phase III clinical program in combination with standard-of-care (SoC) therapy in AL amyloidosis. Two parallel Phase III trials in patients with Mayo stage IIIa disease and in patients with Mayo stage IIIb disease respectively are ongoing.

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